COLON CANCER: Darren D. Browning, PhD, received a 5-year, $1.8M R01 grant from NIH/NCI

DarrenBrowningwebDarren D. Browning, PhD, Biochemistry and Molecular Biology, received a 5-year, $1.8M R01 grant from NIH/NCI for “Colon cancer chemoprevention with phosphodiesterase-5 inhibitors.”

Chronic inflammation in the colon is a risk factor for tumor initiation and progression. The colon is lined by a layer of epithelial cells, which serves as a barrier to inflammation, protecting underlying tissues from inflammatory triggers in the colon’s contents. In the epithelial layer, a small messenger molecule called cGMP initiates a molecular signaling cascade that is tumor-suppressive.  Dr. Browning’s studies are unraveling the signaling mechanism and are investigating ways to exploit this natural process as a way to prevent and treat colon cancer. One method involves the use of therapeutics (such as Viagra) that are known to inhibit the breakdown of cGMP, thereby maintaining the tumor-suppressive role.  Finding new uses for already-approved drugs expedites the translation of scientific findings to the clinic as novel therapeutic strategies.

News of this research was featured in the Augusta Chronicle and was covered by ABC News Radio, The Huffington Post, and NBC News.

Written by
Heather Hopkins

My work explores the relationship between the universality of myth and life as performance.

With influences as diverse as Machiavelli and Joni Mitchell, new combinations are generated from both explicit and implicit meanings.

Ever since I was a teenager I have been fascinated by the essential unreality of the zeitgeist. What starts out as yearning soon becomes corroded into a manifesto of professional courtesy, leaving only a sense of what could have been and the dawn of a new reality.

As momentary replicas become clarified through emergent and repetitive practice, the viewer is left with an epitaph for the outposts of our culture.

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Written by Heather Hopkins

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