Chronic inflammation in the colon is a risk factor for tumor initiation and progression. The colon is lined by a layer of epithelial cells, which serves as a barrier to inflammation, protecting underlying tissues from inflammatory triggers in the colon’s contents. In the epithelial layer, a small messenger molecule called cGMP initiates a molecular signaling cascade that is tumor-suppressive. Dr. Browning’s studies are unraveling the signaling mechanism and are investigating ways to exploit this natural process as a way to prevent and treat colon cancer. One method involves the use of therapeutics (such as Viagra) that are known to inhibit the breakdown of cGMP, thereby maintaining the tumor-suppressive role. Finding new uses for already-approved drugs expedites the translation of scientific findings to the clinic as novel therapeutic strategies.