Blood cancer and heat shock factors

Nahid F. Mivechi, PhD, received a $1.3M, 5-year R01 grant from NIH/NCI for โ€œRole of Heat Shock Factors (Hsfs) in Tumorigenesis.โ€

This research will investigate the molecular mechanisms that cause and drive the T-cell subtype of acute lymphoblastic leukemia (T-ALL), a form of blood cancer. Studies have shown that patients with primary and relapse T-ALLs, as well as laboratory models of T-ALL, have a very high incidence of activated Notch1 protein and mutated (inactivated) tumor suppressor protein, TP53. Dr. Mivechiโ€™s group has found that deletion of heat shock factors (Hsfs) Hsf4, Hsf2, or Hsf1 in TP53-deficient mice leads to significant protection against the development of T-ALL, suggesting that therapeutic inhibition of Hsfs could be a key to eliminating T-ALL. Research funded by this R01 will test the hypothesis that although Hsfs are not essential for T cell development, they cooperate with oncogenes and tumor suppressor genes to control T-ALL development, and that depletion of Hsfs result in the inability of T-ALL cells to survive.

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Heather Hopkins

My work explores the relationship between the universality of myth and life as performance.

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Ever since I was a teenager I have been fascinated by the essential unreality of the zeitgeist. What starts out as yearning soon becomes corroded into a manifesto of professional courtesy, leaving only a sense of what could have been and the dawn of a new reality.

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Written by Heather Hopkins

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