Experimental compound to restore microvascular function in blood disorders

Phase 3 Clinical Trial for Sickle Cell Disease:  Betty Pace, MD, received a $178K, 2-year  award from Mast Therapeutics, Inc. for “MST-188-01: Evaluation of Purified Poloxamer 188 in Children in Crisis (EPIC): A Phase 3 Randomized, Double blind, Placebo-Controlled Multicenter Trial of MST-188.”

The EPIC study will test an experimental compound called MST-188, which is designed to restore microvascular function that is compromised in a number of diseases, including sickle cell disease (SCD).  Specifically, the EPIC study will evaluate whether MST-188 can reduce 1) the duration of vaso-occlusive crisis (VOC) in subjects with SCD, and 2) the frequency of re-hospitalization due to a recurrence of VOC.  EPIC will also investigate the development of acute chest syndrome during VOC in subjects who receive MST-188.  The study officially opened at GRU on November 1, 2013 and will enroll nearly 400 individuals aged 8-17 with sickle cell anemia from participating academic centers across the United States through December 2015.

Written by
Heather Hopkins

My work explores the relationship between the universality of myth and life as performance.

With influences as diverse as Machiavelli and Joni Mitchell, new combinations are generated from both explicit and implicit meanings.

Ever since I was a teenager I have been fascinated by the essential unreality of the zeitgeist. What starts out as yearning soon becomes corroded into a manifesto of professional courtesy, leaving only a sense of what could have been and the dawn of a new reality.

As momentary replicas become clarified through emergent and repetitive practice, the viewer is left with an epitaph for the outposts of our culture.

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Written by Heather Hopkins

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