Ali Arbab, MD, PhD, brings to the GRU Cancer Center the remaining $94K of his NCI/NIH R01 grant…

Ali Arbab, MD, PhD
Ali Arbab, MD, PhD
Ali Arbab, MD, PhD
Ali Arbab, MD, PhD
Ali Arbab, MD, PhD, brings to the GRU Cancer Center the remaining $94K of his NCI/NIH R01 grant, “In vivo detection of involvement of endogenous BM progenitor cells in glioma” that was awarded during his time at the Henry Ford Health System.

The proposed investigations will shed new lights on the mechanisms of tumor neovascularization following anti-angiogenic/anti-vasculogenic treatments and apply both optical and MR imaging techniques to track changes in the tumor. Specifically, researchers will: 1) create a chimeric animal model by replacing bone marrow cells with GFP+ bone marrow, 2) use established imaging modalities and techniques to determine, in vivo, the changes in the tumors during anti-angiogenic/anti-vasculogenic treatments, 3) track the migration of endogenous GFP+ bone marrow progenitor cells to the sites of tumor, using optical imaging, 4) use exogenous stem cells to determine the role of stem cells during anti-angiogenic/anti-vasculogenic treatments by MRI, and 5) use both optical imaging and cellular MRI to track how progenitor cells become involved in tumor angiogenesis/vasculogenesis during anti-angiogenic/anti-vasculogenic treatments.

 

Written by
Allison Brown
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Written by Allison Brown

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