Volume 1, Issue 10

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Announcements
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Cancer Awareness Month
July Cancer Awareness Ribbons
July is…
  • Sarcoma Awareness
  • Bladder Cancer Awareness
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We Asked a Caregiver: Kerrie Harmon
Kerrie Harmon CC:Report is proud to present the next installment of our regular feature highlighting a caregiver working at the GRU Cancer Center. Read more…
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New Faculty
Waleed Mourad, M.D. Dr. Waleed Mourad, MBBCH, PhD, Associate Professor of Radiation Oncology; Co-leader, Head & Neck Multidisiplinary Team
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Employee Art Exhibit
Employee Art Exhibit GRU Cancer Center Employee Art Exhibit
Opening Reception

Thursday, July 17
4 pm, CN1102 lobby
Light refreshments provided
.

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Marketing Services Request
If your office or department requires marketing materials such as brochures, videos, pamphlets, website, etc, please submit the required Marketing Request form. The request form includes vital information regarding content, purpose, audience and budget essential for prioritization, development and production. Read more…
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We Are the World

Director's Corner: Samir N. Khleif, MD
“I want to go to the World Cup. I want to go to the Masters. I want to go…anywhere.”Michael Phelps

The world moves fast. We are all, seemingly, in constant motion – dashing from here to there and from one task to another. It can, at times, become difficult to focus. And while we may not always welcome distraction, sometimes that’s exactly what is needed to remind us of what is important.

Recently, that welcome distraction was the World Cup.

For the past few weeks, the world has slowed some of its scurry and focused with interest and pride on game results being beamed from Brazil. And while the level of interest and intensity in the United States might not equal that in countries with more established football – or soccer as the case may be – cultures, its affect has still been felt here at the GRU Cancer Center. This is, of course, due in part to the international nature of our faculty and staff. But it’s also because that sense of connection, of being part of some larger than ourselves, is what has attracted many of us to this field of work and study.

Earlier this week, we streamed both the Brazil-Germany and Argentina-Netherlands games and it was interesting to see how effectively this did bring people together. It wasn’t about rowdy rooting for one side or another or the loud cheers and boos that often accompany these games. It was about coming together and enjoying the shared moment. And that, in many ways, is what is wonderful about the Cancer Center. While we all work with our individual projects and patients, we can always come together and, taking pride in our collective accomplishments, pause and share that moment.

Have you Heard…?

  • GRU, a Georgia Leader in 3D Mammograms
    On June 25, 2014, The Journal of the American Medical Association (JAMA) published a study showing that digital mammography in combination with tomosynthesis (3D mammography) decreases the need for for additional testing, which often confirms false positive results, and increases the rate of detecting cancer. >> Continue reading
  • Happy Birthday, from Dr. Khleif
    As a way to honor Cancer Center faculty and staff, all are invited to a special break during their birthday month. Launched in June, “Coffee with Khleif” is an opportunity to join with others in the Cancer Center who share the same birthday month … >> Continue reading

Featured Research

  • Non-Small Cell Lung Cancer: A recent investigation led by Feng-Ming (Spring) Kong, MD, PhD, Chair of the Department of Radiation Oncology and Co-Leader of the GRU Cancer Center Lung Cancer Disease-Site Working Group, studied the effect of high-dose radiation to the pulmonary artery on overall and median survival in 100 patients with inoperable/unresectable non-small cell lung cancer (NSCLC) treated with or without concurrent chemotherapy.  >> Continue reading

Grant News

  • Ali Syed Arbab, MBBS, PhD, brings to the GRU Cancer Center the remaining 3 years, $1.06M of his 5-year NCI/NIH R01 grant, “Understanding mechanisms of resistance to anti-angiogenic treatments” that was awarded during his time at Henry Ford Hospital in Detroit, MI. Project Description:  The results of this research are expected to lead to a better understanding of the mechanisms of resistance to anti-angiogenic treatments for glioblastoma (GBM, a type of glioma brain tumor) and other solid tumors. Using an experimental model of human glioma, investigators will test a new agent that targets multiple sites of angiogenesis.  Effects of this new compound, alone and in combination with an existing angiogenesis inhibitor, will be measured using dynamic contrast-enhanced MRI (DCE-MRI), an accurate and sensitive non-invasive technique that detects tumor volume, tumor blood volume, and tumor vascular parameters such as perfusion, permeability, and extravascular-extracellular space volume. The research will also examine whether blocking SDF-1 (a pro-angiogenic factor) or decreasing bone marrow-derived precursor cells helps overcome resistance to anti-angiogenic therapy.  At present, survival from malignant GBM is typically less than a year, making even a partial response a potentially relevant lead for therapeutic improvement.
  • Yan Cui, PhD, brings to the GRU Cancer Center the remaining 4 years, $1.25M, of her 5-year NCI/NIH R01 grant, “P53 inactivation on MDSC development and tumor progression” that was awarded during her time at Louisiana State University. Trp53 inactivation is one of the leading causes of cancer. Interestingly p53 inactivation is also induced in various physiological and pathological conditions by viral infection, oncogene activation, and aging process, some of which have been linked to tumorigenesis. The novel concepts on the immunological mechanism of p53 dysfunction/inactivation in tumorigenesis developed in this project will not only broaden our understanding of the largely unappreciated immunomodulatory function of p53 in tumor suppression, but also provide valuable insights into new strategies targeting the p53 pathway in the tumor microenvironment that can be implemented to new tumor immunotherapies.
  • Daqing Wu, PhD, brings to the GRU Cancer Center the remaining year, $104K, of his 3-year NCI/NIH R21 grant, “EPLIN as a molecular target of genistein in preventing prostate cancer metastasis” that was awarded during his time at Emory University in Atlanta. Consumption of genistein, a major dietary isoflavone, has been associated with decreased rate of metastasis and reduced risk of mortality in prostate cancer patients. However, the mechanism of action of genistein in blocking the metastatic cascade in cancer cells remains largely unknown. This research will perform in vitro and in vivo studies to elucidate a novel mechanism of action of genistein in inhibiting the acquisition of invasiveness in human prostate cancer cells. The proposed studies will provide mechanistic basis and rationale for clinical investigation of genistein in preventing metastasis at early stages of tumor progression, therefore significantly contributing to our efforts of diverting lethal cancer into a chronic disease.

New Clinical Trial

  • Shou-Ching Tang, MD, PhD, received $115K from Janssen Research & Development, L.L.C., for “A Phase 1 Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of JNJ-42756493, a Pan-Fibroblast Growth Factor Receptor (FGFR) Tyrosine Kinase Inhibitor, in Subjects with Advanced or Refractory Solid Tumors or Lymphomas.

Recent Publications

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