Andrew Mellor, PhD, received a $1.5M, 4-year R01 grant from NIAID/NIH for “Engineering DNA nanoparticles to create immune tolerance.”

Dr. Mellor’s laboratory has observed physiologic responses to DNA nanoparticles in mice, founding a completely novel approach to manipulating immune responses and protecting healthy tissues from destruction during autoimmune syndromes. This grant will explore key elements of the pathway targeted by the DNA nanoparticles and will engineer vaccines to protect healthy tissues at risk of immune-mediated destruction in mouse models of clinical autoimmune syndromes. DNA nanoparticles are also used to incite anti-tumor immunity, and a future direction is to evaluate if cancer therapeutic responses to DNA nanoparticles are sub-optimal due to the tolerogenic responses documented by Dr. Mellor’s laboratory.

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Allison Brown
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Written by Allison Brown

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