Augusta University
Allison Brown
The proposed investigations will shed new lights on the mechanisms of tumor neovascularization following anti-angiogenic/anti-vasculogenic treatments and apply both optical and MR imaging techniques to track changes in the tumor. Specifically, researchers will: 1) create a chimeric animal model by replacing bone marrow cells with GFP+ bone marrow, 2) use established imaging modalities and techniques to determine, in vivo, the changes in the tumors during anti-angiogenic/anti-vasculogenic treatments, 3) track the migration of endogenous GFP+ bone marrow progenitor cells to the sites of tumor, using optical imaging, 4) use exogenous stem cells to determine the role of stem cells during anti-angiogenic/anti-vasculogenic treatments by MRI, and 5) use both optical imaging and cellular MRI to track how progenitor cells become involved in tumor angiogenesis/vasculogenesis during anti-angiogenic/anti-vasculogenic treatments.
