Anatolij Horuzsko, MD, PhD, received a 5-year, $1.6M R01 grant from NCI/NIH for “TREM-1 and Its Implications to Cancer
A connection between inflammation and cancer has been long suspected. The Horuzsko laboratory has identified mechanisms of chronic inflammation leading to liver carcinogenesis – and that this process can be diminished by inhibiting a molecule called TREM-1 in experimental models. This R01 will support further research studying the role of TREM-1 in controlling initiation and progression of liver tumorigenesis. The knowledge gained should help develop strategies for potent anti-cancer prevention and novel clinical and preclinical therapeutic approaches that target the immune and non-immune components of liver tumors. Additionally, this research may benefit patients with a variety of inflammatory diseases, including allergy and autoimmune diseases.