Volume 1, Issue 3

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New Faces
celis Esteban Celis, MD, PhD Cancer Immunology, Inflammation & Tolerance
Upcoming Events
GRU Cancer Center’s Holiday Luncheon
Thursday, December 19
11:30am – 1:30pm
CN Building, 1st Floor
Branding Materials Online
Download letterhead, power point templates, research poster templates, and more. Visit our Branding & Identity page now.
Patient & Program Outcomes Report
Each year, the Cancer Committee develops and disseminates a report of patient or program outcomes to the public. Visit Outcomes Report now.

FInder Keeper
The first person to correctly identify what this is a photograph of will win one of these lovely-and-limited Cancer Center coffee mugs.
Click to submit your answer…


Volume 1, Issue 2
Volume 1, Issue 1
‘Tis the Season to be Thankful

Director's Corner: Samir N. Khleif, MD

“Coming together is a beginning. Keeping together is progress. Working together is success.” Henry Ford

Looking back over the past year, I have a lot to be thankful for. The GRU Cancer Cancer has grown by leaps and bounds. New programs have been established. It’s reputation, in both the medical community and the community in general, is stronger than ever. We are in the midst of an exceptional medical success story fueled by the most valuable asset any organization can acquire…. People. Read more >>

Have you Heard…?
Grant News
  • Blood cancer and heat shock factors: Nahid F. Mivechi, PhD, received a $1.3M, 5-year R01 grant from NIH/NCI for “Role of Heat Shock Factors (Hsfs) in Tumorigenesis.” Read description >>
  • Toward pediatric cancer clinical trials: Theodore S. Johnson, MD, PhD, received a $375K, 3-year award from Alex’s Lemonade Stand Foundation (ALSF) for “IDO-Based Immunotherapy for Pediatric Brain Tumors.” Read description >>
  • Experimental compound to restore microvascular function in blood disorders: Betty Pace, MD, received a $178K, 2-year  award from Mast Therapeutics, Inc. for “MST-188-01: Evaluation of Purified Poloxamer 188 in Children in Crisis (EPIC): A Phase 3 Randomized, Double blind, Placebo-Controlled Multicenter Trial of MST-188.” Read description >>
Newly Activated Clinical Trials
  • Sharad A. Ghamande, MD, received $434K from EMD Serono, Inc./Merck Serono S.A. for “Phase II Randomized Double Blind Placebo Controlled Trial of Combination of Pimasertib and SAR245409 or of Pimasertib with SAR245409 Placebo in Subjects with Previously Treated Unresectable Low Grade Ovarian Cancer.”
  • Olivier Rixe, PhD, MD, received $43K from Sanofi-Aventis for “International, Multi-Center, Open-Label, Treatment Extension Study of Iniparib as Monotherapy or in Combination Chemotherapeutic Regimens in Cancer Patients Who Have Derived Clinical Benefit from Iniparib Following Completion of a Phase I,II or III Parental Study.”  
  • Jeremy Pantin, MBBS, received $14K from Novartis for “An Open-Label Multi-Center Single Agent Panobinostat Rollover Protocol for Patients who have Completed a Previous Novartis-Sponsored Panobinostat Study and are Judged by the Investigator to Benefit from Continued Single Agent Panobinostat Treatment.”
Recent Publications
  • Amino Acid Depletion and Immune Responsiveness
    Liu H, Huang L, Bradley J, Liu K, Bardhan K, Ron D, Mellor AL, Munn DH, McGaha TL. GCN2 dependent metabolic stress is essential for cytokine induction and pathology in murine sepsis. Mol Cell Biol. 2013 Nov 18. [Epub ahead of print]  See Abstract >>
  • Gastric Cancer and Mycophenolic Acid
    Dun B, Sharma A, Teng Y, Liu H, Purohit S, Xu H, Zeng L, She JX. Mycophenolic Acid Inhibits Migration and Invasion of Gastric Cancer Cells via Multiple Molecular Pathways. PLoS One. 2013 Nov 15;8(11):e81702. See Abstract >>
  • Biomarkers for Ovarian Cancer:  Wang J, Sharma A, Ghamande SA, Bush S, Ferris D, Zhi W, He M, Wang M, Wang X, Miller E, Hopkins D, Macfee M, Guan R, Tang J, She JX. Serum protein profile at remission can accurately assess therapeutic outcomes and survival for serous ovarian cancer. PLoS One. 2013 Nov 11;8(11):e78393. See Abstract >>
  • Autoantibodies and Myasthenia Gravis:  Shen C, Lu Y, Zhang B, Figueiredo D, Bean J, Jung J, Wu H, Barik A, Yin DM, Xiong WC, Mei L. Antibodies against low-density lipoprotein receptor-related protein 4 induce myasthenia gravis.  J Clin Invest. 2013 Nov 8. [Epub ahead of print] See Abstract >>
  • Chemotherapeutic Drug Etoposide Treats Immunoregulatory Disorder:  Johnson TS, Terrell CE, Millen SH, Katz JD, Hildeman DA, Jordan MB. Etoposide Selectively Ablates Activated T Cells To Control the Immunoregulatory Disorder Hemophagocytic Lymphohistiocytosis. J Immunol. 2013 Nov 20. [Epub ahead of print] See Abstract >>
  • Molecular mechanism linking colon bacteria and colon health: Transporters and receptors for short-chain fatty acids as the molecular link between colonic bacteria and the host. Ganapathy V, Thangaraju M, Prasad PD, Martin PM, Singh N. Curr Opin Pharmacol. 2013 Dec;13(6):869-74. See Abstract >>
  • Betaine and Ion Channel Activation: Peden AS, Mac P, Fei YJ, Castro C, Jiang G, Murfitt KJ, Miska EA, Griffin JL, Ganapathy V, Jorgensen EM. Betaine acts on a ligand-gated ion channel in the nervous system of the nematode C. elegans. Nat Neurosci. 2013 Dec;16(12):1794-801. See Abstract >>
  • Keratinocyte Proliferation and Differentiation: Qin H, Bollag WB. The caveolin-1 scaffolding domain Peptide decreases phosphatidylglycerol levels and inhibits calcium-induced differentiation in mouse keratinocytes. PLoS One. 2013 Nov 13;8(11):e80946. See Abstract >>
  • -Globin Regulation, Hematopoiesis, and Hemoglobinopathies: Liu L, Karmakar S, Dhar R, Mahajan M, Choudhury A, Weissman S, Pace BS. Regulation of Gγ-Globin Gene by ATF2 and Its Associated Proteins through the cAMP-Response Element. PLoS One. 2013 Nov 6;8(11):e78253. See Abstract >>
  • Mechanism behind Negative Effects of Antibiotics on the Intestine: Cresci G, Nagy LE, Ganapathy V. Lactobacillus GG and Tributyrin Supplementation Reduce Antibiotic-Induced Intestinal Injury. JPEN J Parenter Enteral Nutr. 2013 Nov-Dec;37(6):763-74. See Abstract >>


Meeting Announcement: The 2014 Stephenson Cancer Center (SCC) International Conference holds the 1st Annual Meeting of the Ovarian Cancer Consortium: Tumor Microenvironment and Drug Discovery, to take place February 9-11, 2014 at the Samis Education Center, University of Oklahoma Health Sciences Center. This meeting boasts an International panel of organizers and Keynote Address by Dr. Tony Hunter of the Salk Institute.  For more information, please click here.
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Jagwire is the official source for news and stories from Augusta University and AU Health. Daily updates highlight the many ways students, faculty, staff, researchers and clinicians "bring their A games" in classrooms and clinics on four campuses in Augusta and locations across the state of Georgia. Read on for stories of innovation in education and health care, opportunities at the center of Georgia’s new cybersecurity hub, and experiential learning that blends arts and application, humanities and the health sciences. Have a story to share with Jaguar Nation? Contact the Division of Communications & Marketing.
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