|Yan Cui, PhD, Associate Professor in the Department of Biochemistry and Molecular Biology|
|Joseph Kaminiski, MD Associate Professor in the Department of Radiation Oncology|
Also New to the Cancer Center
Frank E. Mott, MD, FACP: for recently being appointed to the Editorial Board of the Journal of Epidemiology and Preventive Medicine
|Prevention is the best medicine
“The doctor of the future will give no medicine, but will interest his patients in the care of the human frame, in diet, and in the cause and prevention of disease.”— Thomas Alva Edison
February is Cancer Prevention Month and setting aside time to focus on the work being done, and yet to be done, is as important as ever.
A recent report by the United Nation’s International Agency for Research on Cancer (IARC) shows that an estimated 8.2 million people died from cancer in 2012, that cancer incidence over a four year period leading up to 2012 rose by 11 percent and that, at this rate, cancer cases will rise by 75 percent over the next 20 years.
This does not mean cancer has become more difficult to treat On the contrary, advances are being made every day, many right here at the GRU Cancer Center. Remission is a word we are able to use far more often than ever before. So why are rates rising? It’s an issue of disparity and education.
Not everyone in the world has that kind of treatment options available that we are proud to provide. Not everyone in the world has access to the information we are able to disseminate so freely. The (IARC) study estimates that by 2025, almost 80 percent of all cancer deaths will occur in less economically-developed regions of the world. That’s what makes Cancer Prevention Month – a month focused on the global issue of preventing cancer before it occurs – so important. It reminds us that it is patients, not a disease, that we are treating and that sometimes, it is also a behavior.
Have you Heard…?
- GRU Cancer Center expresses gratitude for million gift
On Tuesday, February 18, the Masters Tournament and the Augusta National Golf Club through the Community Foundation honored Augusta’s GRU Cancer Center …>> Continue reading.
- GRU Cancer Center partners with Advaxis to conduct four clinical trials
Advaxis Inc., a biotechnology company specializing in cancer immunotherapies, announced it has expanded its relationship with the GRU Cancer Center…>> Continue reading.
- Johnson’s Lemonade Stand
For Dr. Theodore Johnson, setting up a lab focused on the treatment of pediatric brain cancer in Augusta meant more than merely staking his claim as part of a successful and expanding program. >> Continue reading
- Cancer Biology Trainee Town Hall Re-Cap
On January 17, 2014, GRU Cancer Center Cancer Biology trainees gathered for the first-ever Cancer Biology Trainee Town Hall, presented by Drs. Maihle, Browning, and Khleif. >> Continue reading
- GRU Cancer Center Basic Science Pilot Awards
The GRU Cancer Center is pleased to announce the awardees of the Basic Science Pilot Awards! Four projects were awarded out of a total of 21 applications. >> Continue reading
Newly Activated Clinical Trials
- Olivier Rixe, MD, PhD, received $1.1M from EMD Serono, Inc./Merck Serono S.A. for “A Phase 1, Open-Label, Multiple-Ascending Dose Trial to Investigate the Safety, Tolerability, Pharmacokinetics, Biological and Clinical Activity of MSB0010718C in Subjects with Metastatic or Locally Advanced Solid Tumors and Expansion to Selected Indications.”
- Samir N. Khleif, MD, received $516K from Medimmune, Inc. for “A Phase 2, Randomized, Double-Blind Study Comparing Tremelimumab to Placebo Second-or Third-Line Treatment of Subjects with Unresectable Pleural or Peritoneal Malignant Mesothelinoma.”
- John G. Stewart, MD, received $80K from the American College of Radiology Imaging Network for “(RTOG 1106/ACRIN6697) Randomized Phase II Trial of Individual Adaptive Radiationtheraphy using During-Treatment FDG-PET/CT & Modern Technology in Locally Advanced NSCLC.”
- Zhu H, Pollock NK, Kotak I, Gutin B, Wang X, Bhagatwala J, Parikh S, Harshfield GA, Dong Y. Dietary Sodium, Adiposity, and Inflammation in Healthy Adolescents. Pediatrics. 2014 Feb 2. [Epub ahead of print] >> Go to Abstract, PMID: 24488738
- Yang AX, Chong N, Jiang Y, Catalano J, Puri RK, Khleif SN. Molecular characterization of antigen-Peptide pulsed dendritic cells: immature dendritic cells develop a distinct molecular profile when pulsed with antigen Peptide. PLoS One. 2014 Jan 27;9(1):e86306. doi: 10.1371/journal.pone.0086306. eCollection 2014. >> Go to Abstract, PMID: 24475103
- Kutlar F, Unguru Y, Dixon N, Patel N, Bailey L, Zhuang L, Carmichael H, Kutlar A. Hemoglobin. 2014 Jan 29. Two New Hemoglobin Variants: Hb Tallahassee [α3(A1)Ser→Tyr; HBA2: c.11C>A] and Hb Madison-NC [β119(GH2)Gly→Ser; HBB: c.358G>A]. [Epub ahead of print] >> Go to Abstract, PMID: 24471829
- Ha Y, Shanmugam AK, Markand S, Zorrilla E, Ganapathy V, Smith SB. Sigma receptor 1 modulates ER stress and Bcl2 in murine retina. Cell Tissue Res. 2014 Jan 28. [Epub ahead of print] >> Go to Abstract, PMID: 24469320
- Yuan ST, Brown RK, Zhao L, Ten Haken RK, Gross M, Cease KB, Schipper M, Stanton P, Yu J, Kong FM. Timing and intensity of changes in FDG uptake with symptomatic esophagitis during radiotherapy or chemo-radiotherapy. Radiat Oncol. 2014 Jan 27;9(1):37. [Epub ahead of print] >> Go to Abstract, PMID: 24467939
- Ananth S, Gnana-Prakasam JP, Bhutia YD, Veeranan-Karmegam R, Martin PM, Smith SB, Ganapathy V. Regulation of the cholesterol efflux transporters ABCA1 and ABCG1 in retina in hemochromatosis and by the endogenous siderophore 2,5-dihydroxybenzoic acid. Biochim Biophys Acta. 2014 Jan 23. pii: S0925-4439(14)00022-2. doi: 10.1016/j.bbadis.2014.01.010. [Epub ahead of print] >> Go to Abstract, PMID: 24462739
- Krafft CE, Schaeffer DJ, Schwarz NF, Chi L, Weinberger AL, Pierce JE, Rodrigue AL, Allison JD, Yanasak NE, Liu T, Davis CL, McDowell JE. Improved Frontoparietal White Matter Integrity in Overweight Children Is Associated with Attendance at an After-School Exercise Program. Dev Neurosci. 2014 Jan 21. [Epub ahead of print] >> Go to Abstract, PMID: 24457421
- Ho B, Jang DW, Van Rompaey J, Figueroa R, Brown JJ, Carrau RL, Solares CA. Landmarks for Endoscopic Approach to the Parapharyngeal Internal Carotid. Laryngoscope. 2014 Jan 21. doi: 10.1002/lary.24601. [Epub ahead of print] >> Go to Abstract, PMID: 24449498
- Mason E, Gurrolaii J, Reyes C, Brown JJ, Figueroa R, Solares CA. Analysis of the petrous portion of the internal carotid artery: Landmarks for an endoscopic endonasal approach. Laryngoscope. 2014 Jan 20. doi: 10.1002/lary.24594. [Epub ahead of print] >> Go to Abstract, PMID: 24442967
- Arthur ME, Odo N, Parker W, Weinberger PM, Patel VS. CASE 0-2013: Supracarinal Tracheal Tear after Atraumatic Endotracheal Intubation: Anesthetic Considerations for Surgical Repair. J Cardiothorac Vasc Anesth. 2014 Jan 16. pii: S1053-0770(13)00491-6. doi: 10.1053/j.jvca.2013.08.014. [Epub ahead of print] >> No abstract available, PMID: 24442967
- Urken ML, Milas M, Randolph GW, Tufano R, Bergman D, Bernet V, Brett EM, Brierley JD, Cobin R, Doherty G, Klopper J, Lee S, Machac J, Mechanick JI, Orloff LA, Ross D, Smallridge RC, Terris DJ, Clain JB, Tuttle M. A review of the management of recurrent and persistent metastatic lymph nodes in well differentiated thyroid cancer: A multifactorial decision making guide created for the Thyroid Cancer Care Collaborative. Head Neck. 2014 Jan 17. doi: 10.1002/hed.23615. [Epub ahead of print] >> Go to Abstract, PMID: 24436291
- Itokazu Y, Yu RK. Amyloid β-Peptide 1-42 Modulates the Proliferation of Mouse Neural Stem Cells: Upregulation of Fucosyltransferase IX and Notch Signaling. Mol Neurobiol. 2014 Jan 17. [Epub ahead of print] >> Go to Abstract, PMID: 24436056
- Promsote W, Veeranan-Karmegam R, Ananth S, Shen D, Chan CC, Lambert NA, Ganapathy V, Martin PM. L-2-oxothiazolidine-4-carboxylic acid attenuates oxidative stress and inflammation in retinal pigment epithelium. Mol Vis. 2014 Jan 7;20:73-88. eCollection 2014. >> Go to Abstract, PMID: 24426777
- Paschall AV, Zimmerman MA, Torres CM, Yang D, Chen MR, Li X, Bieberich E, Bai A, Bielawski J, Bielawska A, Liu K. Ceramide targets xIAP and cIAP1 to sensitize metastatic colon and breast cancer cells to apoptosis induction to suppress tumor progression. BMC Cancer. 2014 Jan 15;14(1):24. doi: 10.1186/1471-2407-14-24. >> Go to Abstract, PMID: 24422988
- Berger PK, Principe JL, Laing EM, Henley EC, Pollock NK, Taylor RG, Blair RM, Baile CA, Hall DB, Lewis RD. Weight gain in college females is not prevented by isoflavone-rich soy protein: a randomized controlled trial. Nutr Res. 2014 Jan;34(1):66-73. doi: 10.1016/j.nutres.2013.09.005. Epub 2013 Oct 22. >> Go to Abstract, PMID: 24418248
- Singh N, Gurav A, Sivaprakasam S, Brady E, Padia R, Shi H, Thangaraju M, Prasad PD, Manicassamy S, Munn DH, Lee JR, Offermanns S, Ganapathy V. Activation of gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis. Immunity. 2014 Jan 16;40(1):128-39. doi: 10.1016/j.immuni.2013.12.007. Epub 2014 Jan 9. >> Go to Abstract, PMID: 24412617
- Metz R, Smith C, Duhadaway JB, Chandler P, Baban B, Merlo LM, Pigott E, Keough MP, Rust S, Mellor AL, Mandik-Nayak L, Muller AJ, Prendergast GC. IDO2 is critical for IDO1-mediated T-cell regulation and exerts a non-redundant function in inflammation. Int Immunol. 2014 Jan 13. [Epub ahead of print] >> Go to Abstract, PMID: 24402311
- Blackburn AR 2nd, Hamrick MW, Chutkan N, Sangani R, Waller JL, Corpe R, Prasad PD, Isales CM, Ganapathy V, Fulzele S. Comparative analysis of sodium coupled vitamin C transporter 2 in human osteoarthritis grade 1 and grade 3 tissues. BMC Musculoskelet Disord. 2014 Jan 8;15(1):9. [Epub ahead of print] >> Go to Abstract, PMID: 24401033
- Nagato T, Lee YR, Harabuchi Y, Celis E. Combinatorial Immunotherapy of Polyinosinic-Polycytidylic Acid and Blockade of Programmed Death-1 Induces Effective CD8 T Cell Responses against Established Tumors. Clin Cancer Res. 2014 Jan 30. [Epub ahead of print] >> Go to Abstract, PMID: 24389326
- Mehta SH, Switzer JA, Biddinger P, Rojiani AM. IgG4-related leptomeningitis: A reversible cause of rapidly progressive cognitive decline. Neurology. 2014 Jan 2. [Epub ahead of print] >> Go to Abstract, PMID: 24384648
- Huang L, Mellor AL. Metabolic control of tumour progression and antitumour immunity. Curr Opin Oncol. 2014 Jan;26(1):92-9. doi: 10.1097/CCO.0000000000000035. >> Go to Abstract, PMID: 24305570
- Johnson TS, Terrell CE, Millen SH, Katz JD, Hildeman DA, Jordan MB. Etoposide selectively ablates activated T cells to control the immunoregulatory disorder hemophagocytic lymphohistiocytosis. J Immunol. 2014 Jan 1;192(1):84-91. doi: 10.4049/jimmunol.1302282. Epub 2013 Nov 20. >> Go to Abstract, PMID: 24259502
- Liu H, Huang L, Bradley J, Liu K, Bardhan K, Ron D, Mellor AL, Munn DH, McGaha TL. GCN2-Dependent Metabolic Stress Is Essential for Endotoxemic Cytokine Induction and Pathology. Mol Cell Biol. 2014 Feb;34(3):428-38. doi: 10.1128/MCB.00946-13. Epub 2013 Nov 18. >> Go to Abstract, PMID: 24248597
- Doi K, Noiri E, Nangaku M, Yahagi N, Jayakumar C, Ramesh G. Repulsive guidance cue semaphorin 3A in urine predicts the progression of acute kidney injury in adult patients from a mixed intensive care unit. Nephrol Dial Transplant. 2014 Jan;29(1):73-80. doi: 10.1093/ndt/gft414. Epub 2013 Oct 28. >> Go to Abstract, PMID: 24166457
- Ranganathan P, Jayakumar C, Navankasattusas S, Li DY, Kim IM, Ramesh G. UNC5B Receptor Deletion Exacerbates Tissue Injury in Response to AKI. J Am Soc Nephrol. 2014 Feb;25(2):239-49. doi: 10.1681/ASN.2013040418. Epub 2013 Oct 10. >> Go to Abstract, PMID: 24115477
- Tsai YT, Yu RK. Epigenetic activation of mouse ganglioside synthase genes: implications for neurogenesis. J Neurochem. 2014 Jan;128(1):101-10. doi: 10.1111/jnc.12456. Epub 2013 Oct 23. >> Go to Abstract, PMID: 24102378
- Singer MC, Heffernan A, Terris DJ. Defining anatomical landmarks for robotic facelift thyroidectomy. World J Surg. 2014 Jan;38(1):92-5. doi: 10.1007/s00268-013-2246-8. >> Go to Abstract, PMID: 24101022
- Fizazi K, Delva R, Caty A, Chevreau C, Kerbrat P, Rolland F, Priou F, Geoffrois L, Rixe O, Beuzeboc P, Malhaire JP, Culine S, Aubelle MS, Laplanche A. A Risk-adapted Study of Cisplatin and Etoposide, with or Without Ifosfamide, in Patients with Metastatic Seminoma: Results of the GETUG S99 Multicenter Prospective Study. Eur Urol. 2014 Feb;65(2):381-6. doi: 10.1016/j.eururo.2013.09.004. Epub 2013 Sep 13. >> Go to Abstract, PMID: 24094847
- Krafft CE, Schwarz NF, Chi L, Weinberger AL, Schaeffer DJ, Pierce JE, Rodrigue AL, Yanasak NE, Miller PH, Tomporowski PD, Davis CL, McDowell JE. An 8-month randomized controlled exercise trial alters brain activation during cognitive tasks in overweight children. Obesity (Silver Spring). 2014 Jan;22(1):232-42. doi: 10.1002/oby.20518. Epub 2013 Sep 10. >> Go to Abstract, PMID: 23788510